PFAPA SYNDROME

PFAPA SYNDROME

This published case of PFAPA syndrome is periodic fever,adenitis,pharyngitis & aphthous oral ulcerations which occurs on periodically every 1 to 2 months and presents with high fever.since its autoimmune etiology it responds to steroids within a day or 2 and child becomes symptomfree  very soon without any prostration and sequelae.it responds poorly to antibiotics as its noninfective origin.throat swab culture is negative.recently a child with above findings and repeated fever for several years got admitted in raj hospital.he recovered without antibiotics only by inn dexona.he was treated repeatedly by several ent surgeons and very soon tonsillectomy was planned.tonsils were almost kissing.few throat swab had grew stap aureus and was managed accordingly by ent spec.but its very remarkable to note that staph aureus  never causes tonsillitis.patient parents were surprised to be cured without antibiotic ,only by dexona.

Ebv,cmv,FMF has to be r/o before coining Pfafa.

In severe cases interleukin inhibitors can be given.colchicine almost cures the condition but its self limiting .by adolescent it resolves spontaneously and has no long term complications .

Its known to occur in adults but do not resolve spontaneously.

So we shld be aware of this condition for proper explanations and counsel abt its self limiting course  to the parents.staph never causes tonsillitis or pharry gitis and its very common mistake consider it the etiology in any case of tonsillitis.

Hids is similar condition of periodic fever as FMf.any of us is requested to write few lines about these.

So we should be aware of above condition so that many recurrent  above problem can collectively be called PFAFA syndrome.if very problematic then tonsillectomy could be done.